肾小管上皮间充质转化与肾脏纤维化

doi:10.3969/j.issn.1000-4718.2014.10.033

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摘要

[摘要] 在肾脏损伤过程中，多种因子可诱导上皮细胞转化为成纤维细胞/肌成纤维细胞，引起肾小管缺失与细胞外基质蛋白沉积，这一过程被称为上皮间充质转化(epithelial-mesenchymal transition, EMT)。在肾脏损伤或应激时，肾小管上皮细胞发生EMT，对肾脏纤维化具有重要作用。肾小管上皮细胞微环境存在多种调节因子，调控EMT相关信号如TGF-β/Smad、Wnt/β-catenin等的表达与传导。本文就近年来肾小管上皮细胞EMT在肾脏纤维化的作用及机制研究进展进行综述。

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关键词 ：上皮间充质转化, 肾小管间质纤维化, 信号转导

Abstract：

Epithelial-mesenchymal transition (EMT), a process by which differentiated epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing fibroblasts and myofibroblasts, is increasingly recognized as an integral part of tissue fibrogenesis after injury. However, the degree to which renal tubular epithelial EMT contributes to kidney fibrosis remains a matter of intense debate and is likely to be context-dependent. Renal tubular EMT is an adaptive response of epithelial cells to a hostile or changing microenvironment and is regulated by many factors. Several intrace-llular signal transduction pathways such as transforming growth factor-β (TGF-β)/Smad and Wnt/β-catenin signaling are essential in controlling the process of renal tubular epithelial EMT which are potential targets of antifibrotic therapy presently. This review highlights the current understanding of renal tubular epithelial EMT and its underlying mechanisms to stimulate further discussion on its role in the pathogenesis of renal interstitial fibrosis.

Key words： Epithelial-mesenchymal transition Renal interstitial fibrosis Signal transduction

收稿日期: 2014-03-06 出版日期: 2014-10-15

中图分类号:

R692.9

基金资助:

浙江省医药卫生科研基金(No.2012KYB175)；宁波市自然科学基金资助项目(No.2012A610253)

通讯作者: 王来亮 E-mail: nbluoqun@163.com

引用本文:

王来亮,罗群. 肾小管上皮间充质转化与肾脏纤维化[J]. 中国病理生理杂志, 2014, 30(10): 1910-1920.

链接本文:

http://www.cjpp.net/CN/10.3969/j.issn.1000-4718.2014.10.033 或 http://www.cjpp.net/CN/Y2014/V30/I10/1910

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